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Alfa Aesar™ 4alpha-Phorbol 12-myristate 13-acetate, 99%

Negative control for phorbol ester activation of protein kinase C

Brand:  Alfa Aesar™ J61099.#0

Code : NEW

Additional Details : CAS Number : 63597-44-4 Weight : 0.00005kg

Quantity 5mg

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Product Code. 15473749

  • 475.00 € / 5mg


Estimated Shipment date
from Supplier 20-06-2019
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Description

Description

Applications
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Solubility
Soluble in DMSO, methanol or ethanol. Dilute stock solution into aqueous medium at final concentrations of ~2-5µM

Notes
Light sensitive. Incompatible with oxidizing agents and heat.
Specifications

Chemical Identifiers

63597-44-4
616.836
PHEDXBVPIONUQT-LQLWEASQSA-N
122634
C36H56O8
MFCD00153860
4alpha-phorbol 12-myristate 13-acetate, acetoxy-dihydroxy-hydroxymethyl-tetramethyl-oxo-? yl tetradecanoate, phorbol-12-myristate-13-acetate, pma, 4alpha-pma, 4alpha-tpa, .alpha.-tpa, 4.alpha.-tpa, 4alpha-phorbol-12-myristate-13-acetate, 4, a-pma
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

Specifications

4alpha-Phorbol 12-myristate 13-acetate
White
63597-44-4
MFCD00153860
4alpha-phorbol 12-myristate 13-acetate, acetoxy-dihydroxy-hydroxymethyl-tetramethyl-oxo-? yl tetradecanoate, phorbol-12-myristate-13-acetate, pma, 4alpha-pma, 4alpha-tpa, .alpha.-tpa, 4.alpha.-tpa, 4alpha-phorbol-12-myristate-13-acetate, 4, a-pma
PHEDXBVPIONUQT-LQLWEASQSA-N
616.836
616.83
99%
Light Sensitive
5mg
C36H56O8
14,7332
Soluble in DMSO, methanol or ethanol; Dilute stock solution into aqueous medium at final concentrations of ∽2 to 5μM
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
122634
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