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TLK1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538395
Code : NEW
Additional Details : Weight : 0.00900kg
Description
The Tousled-like kinases (TLK1 and TLK2, also designated PKU-beta and PKU-alpha, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regulated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regulate the development of multicellular organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.Specifications
TLK1 | |
Polyclonal | |
Unconjugated | |
TLK1 | |
Serine/threonine-protein kinase tousled-like 1, PKU-beta, Tousled-like kinase 1, TLK-1, KIAA0137, PKU-beta, PKU beta, PKU beta | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
228012, 9874 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q9UKI8, Q8C0V0 | |
TLK1 | |
A synthetic peptide derived from the internal region of human TLK1 | |
100 μg | |
Primary | |
Human, Mouse, Non-human Primate | |
Antibody | |
IgG |