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Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Brand:  Thermo Scientific™ A35396

Additional Details : Weight : 250.00000kg

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Product Code. 15930463

  • 247.00 € / Pack of 10

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Thermo Scientific™ Pierce BS(PEG)n Crosslinkers include BS(PEG)5 and BS(PEG)9, which are bis-succinimide ester-activated PEG compounds for crosslinking between primary amines in proteins and other molecules.

  • A bis-succinimide ester-activated PEG compound used for crosslinking between primary amines (-NH2) in proteins and other molecules
  • The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds
  • Thermo Scientific No-Weigh products are specialty reagents provided in a pre-aliquoted format
  • The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial
  • Enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents, and reducing concerns over reagent stability

Features of BS(PEG)5:

  • Reactive groups: sulfo-NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • NHS esters react with—NH2 groups at pH 7-9, forming stable amide bonds
  • Water-soluble; compare to non-pegylated BS3 (also soluble) and DSS (water-insoluble)
  • Membrane-impermeable, allowing for cell surface labeling
  • Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
  • Polyethylene glycol spacer arms help maintain conjugate solubility
  • Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Ideal for small molecule or peptide conjugations

Alternative Names for BS(PEG)n:

  • Bis-NHS-dPEG
  • BS(PEO)5
  • Bis(NHS)PEO5
  • BS-PEO9
  • dPEG NHS ester
  • Bis-succinimide ester PEG 400


Store desiccated at -5 to -30°C.
No-Weigh™, Pierce™
10 x 1 mg
Room Temperature
Chemical Labeling
Sulfo-NHS Ester


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