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Invitrogen™ Human EGFR His-tag, Recombinant Protein
HEK293 cells Recombinant Protein
87.25 € - 135.00 €
Specifications
Accession Number | P00533 |
---|---|
For Use With (Application) | Control, Functional Assay, Immunohistochemistry, Western Blot |
Formulation | protein with 0.02% Tween 80, 140 mM NaCl, 2.7 mM KCl, 5% mannitol, 5% trehalose and no preservative; pH 7.4 |
Gene ID (Entrez) | 1956 |
Name | Human EGFR His-tag |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17194163
|
Invitrogen™
A42492 |
5 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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17184163
|
Invitrogen™
A42491 |
5 x 5 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.Specifications
P00533 | |
protein with 0.02% Tween 80, 140 mM NaCl, 2.7 mM KCl, 5% mannitol, 5% trehalose and no preservative; pH 7.4 | |
Human EGFR His-tag | |
-20°C | |
<1 EU/μg | |
EGFR | |
Unconjugated | |
Lyophilized |
Control, Functional Assay, Immunohistochemistry, Western Blot | |
1956 | |
HEK293 cells | |
RUO | |
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2 | |
Human | |
Recombinant | |
>95% |