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Invitrogen™ STAR Recombinant Rabbit Monoclonal Antibody (K01_1L32)
Description
STAR Recombinant Monoclonal Antibody for Western Blot
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
Specifications
Specifications
| Antigen | STAR |
| Applications | Western Blot |
| Classification | Recombinant Monoclonal |
| Clone | K01_1L32 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4 |
| Gene | STAR |
| Gene Accession No. | P49675, P51557 |
| Gene Alias | AV363654; cholesterol trafficker; D8Ertd419e; lipid transporter; luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; STAR; StAR related lipid transfer (START) domain containing 1; stARD1; StAR-related lipid transfer (START) domain containing 1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; steroidogenic acute regulatory protein; steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP |
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