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Tetrodotoxin, 99%, Thermo Scientific Chemicals

Catalog Number 13187663
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Quantity:
1 mg
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This item is not returnable. View return policy
Regulatory: Restrictions may apply to the purchase of this product and we may need to request additional documentation from you

Description

Tetrodotoxin, 99%, CAS # 4368-28-9, is a selective voltage-sensitive sodium channel blocker with analgesic activity. It is a toxin found mainly in the liver and gonads of some fish.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Tetrodotoxin is a neurotoxin with analgesic activity

• It is a selective voltage-sensitive sodium channel blocker inhibiting nerve action potential and blocking nerve transmission

• Tetrodotoxin is a potent aminoperhydroquinazoline toxin, and interferes with the transmission of signals from nerves to muscles causing paralysis

• Tetrodotoxin is produced by bacteria such as Vibrio alginolyticus, Pseudoalteromonas tetraodonis, and other vibrio and pseudomonas bacterial species

Applications

• Tetrodotoxin is used as a standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract

• It has also been used to study the effect on low-threshold transient calcium currents in rat hippocampal interneurons

TRUSTED_SUSTAINABILITY
CAS 4368-28-9
Assay Percent Range 99%
Molecular Formula C11H17N3O8
Quantity 1 mg
Beilstein 27, III, 8206
Merck Index 15, 9394
Solubility Information Solubility aq. soln.: insoluble. Other solubilities: soluble in diluted acetic acid, slightly soluble in dry alcohol and ether, practically insoluble in most other common, organic solvents, soluble in acetone
InChI Key SLBCPBUVHCASIJ-UFHSVNPDSA-O
SMILES NC1=[NH+]C(O)C2C3OC4([O-])O[C@@H](C(O)C2(N1)[C@@H]4O)C3(O)CO
IUPAC Name (11S,13S)-3-amino-5,12,13,14-tetrahydroxy-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1⁷,¹¹.0¹,⁶]tetradec-3-en-4-ium-9-olate
Molecular Weight (g/mol) 319.27
Formula Weight 319.26
Chemical Name or Material Tetrodotoxin
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Safety and Handling

compliance-icons
Product Identifier
  • Tetrodotoxin
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Acute toxicity Category 2
 Hazard Statement
  • H310-Fatal in contact with skin.
  • H330-Fatal if inhaled.
  • H300-Fatal if swallowed.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P310-Immediately call a POISON CENTER/doctor/.
  • P361-Take off immediately all contaminated clothing.

RUO – Research Use Only

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