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  6. Invitrogen™ TPMT Recombinant Rabbit Monoclonal Antibody (K01_2P80)

Invitrogen™ TPMT Recombinant Rabbit Monoclonal Antibody (K01_2P80)

Product Code. 30830365
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30830365 50 μL
30829310 100 μL
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Product Code. 30830365 Supplier Invitrogen™ Supplier No. MA565681

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Description

Rabbit Recombinant Monoclonal Antibody

TPMT Recombinant Monoclonal Antibody for IHC (P), Western Blot

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPMT
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone K01_2P80
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene TPMT
Gene Accession No. P51580
Gene Alias AW106912; HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMTD; truncated thiopurine methyltransferase
Gene Symbols TPMT
Host Species Rabbit
Immunogen A synthetic peptide of human TPMT.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7172
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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