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NanoDrop Ultra Spectrophotometers and Fluorometers

Fast, accurate DNA, RNA, and protein quantification, one sample at a time.

How Can Thermo Scientific™ NanoDrop™ Ultra Spectrophotometers and Fluorometers Help You?

Complete Sample Insight in One Measurement

Get both concentration and quality data in a single step using absorbance and fluorescence on one platform. This enables more informed decisions by identifying impurities and differentiating DNA/RNA, reducing the risk of failed downstream experiments.

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Faster, Simplified Workflows

Integrated tools like the qPCR recipe calculator and automated data processing eliminate manual calculations and reduce hands-on time, helping labs increase productivity and achieve consistent, reliable results faster.

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Confidence in Data Accuracy and Quality

Advanced technologies such as Acclaro Sample Intelligence detect contaminants and correct results in real time, ensuring accurate measurements and giving users high confidence in their data—even with complex or impure samples.

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Applicable Solutions

Next-Generation Sequencing (NGS)

Enable a complete and streamlined NGS workflow by combining accurate nucleic acid quantification, advanced sample quality control, and automated library preparation support in a single platform. Using both absorbance and fluorescence, users can quantify samples across a wide dynamic range, while built-in intelligence detects contaminants and corrects results to ensure only high-quality samples proceed to sequencing. Integrated tools simplify reaction setup, reducing manual errors and improving reproducibility. Additionally, seamless data management with LIMS integration and compliance-ready software ensures full traceability and confidence from sample input through sequencing results.

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Accurate NGS Sample Quantification

Ensure optimal library input by accurately quantifying DNA and RNA across a wide dynamic range using both absorbance and fluorescence. This allows users to measure highly concentrated samples without dilution or detect low-abundance samples with high sensitivity—critical for consistent NGS library preparation.

NGS Sample Quality Control (QC)

Evaluate sample purity and integrity before sequencing using advanced contaminant detection (e.g., phenol, proteins, residual DNA/RNA). By identifying and correcting impurities early, users can avoid sequencing failures, reduce costly reruns, and improve overall data quality.

Optimized Library Preparation Workflow

Streamline NGS workflows with integrated tools like the qPCR recipe calculator, which automatically determines reagent volumes based on sample concentration. This reduces manual calculations, minimizes variability, and ensures consistent library preparation across samples.

Confidence in Sequencing Results

Leverage Acclaro™ Sample Intelligence Technology to obtain corrected concentration values and real-time alerts for issues like contaminants or bubbles. This ensures that only high-quality samples proceed to sequencing, improving data reliability and downstream analysis confidence.

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Next Generation Sequencing Sample Preparation

In this note, the NanoDrop Ultra/UltraC Spectrophotometer is shown to be a reliable and sensitive method for quantifying low concentrations of dsDNA upstream of NGS.

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NanoDrop Ultra Acclaro Phenol and Protein Contaminant Identification

Acclaro Sample Intelligence Contaminant ID technology utilizes chemometric algorithms and contaminant spectral libraries to provide predictions regarding the presence of contaminants.

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Frequently Asked Questions

No—most samples can be measured directly without dilution. The NanoDrop Ultra uses microvolume technology with auto-ranging path lengths, allowing accurate measurement of very high concentrations. This saves time, reduces sample handling, and preserves valuable samples.

The system uses Acclaro™ Sample Intelligence Technology to detect common contaminants (e.g., phenol, proteins, residual DNA/RNA) and automatically correct concentration values. This helps ensure reliable results and prevents issues in downstream applications like sequencing or PCR.

Yes. Selected models (e.g., NanoDrop Ultra FL) combine absorbance and fluorescence on a single platform. This allows users to choose fast absorbance measurements for general quantification or highly sensitive fluorescence for low-concentration or complex samples—providing flexibility for a wide range of applications.

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Don’t Just Measure—Understand Your Sample

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