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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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1 – 15 of 184 results
1

PCI-34051, MedChemExpress

MedChemExpress PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 296.32
Color Off-White
Physical Form Solid
Chemical Name or Material PCI-34051
Grade Research
SMILES COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2
For Use With (Application) Cancer-programmed cell death
Percent Purity 97.28%
CAS 950762-95-5
Solubility Information DMSO : ≥ 30 mg/mL (101.24 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C17H16N2O3
Formula Weight 296.32
2

Vinburnine, MedChemExpress

MedChemExpress Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

ENCOMPASS_PREFERRED
3

SB269652, MedChemExpress

MedChemExpress SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.

ENCOMPASS_PREFERRED
4

Apyramide, MedChemExpress

MedChemExpress Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 490.93
Color White
Physical Form Solid
Chemical Name or Material Apyramide
Grade Research
SMILES O=C(OC1=CC=C(NC(C)=O)C=C1)CC2=C(C)N(C(C3=CC=C(Cl)C=C3)=O)C4=C2C=C(OC)C=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.06%
CAS 68483-33-0
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C27H23ClN2O5
Formula Weight 490.93
5

Oncrasin-1, MedChemExpress

MedChemExpress Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 269.73
Color Earth Yellow
Physical Form Solid
Chemical Name or Material Oncrasin-1
Grade Research
SMILES O=CC1=CN(CC(C=C2)=CC=C2Cl)C3=CC=CC=C31
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.28%
CAS 75629-57-1
Solubility Information DMSO : ≥ 43 mg/mL (159.42 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C16H12ClNO
Formula Weight 269.73
6

Metergoline, MedChemExpress

MedChemExpress Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 403.52
Color White
Physical Form Solid
Chemical Name or Material Metergoline
Grade Research
SMILES O=C(OCC1=CC=CC=C1)NC[C@H](C[C@@]23[H])CN(C)[C@]2([H])CC4=CN(C)C5=CC=CC3=C54
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.62%
CAS 17692-51-2
Solubility Information DMSO : 125 mg/mL (309.77 mM; Need ultrasonic)
Health Hazard 1 H302∣H312∣H332
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C25H29N3O2
Formula Weight 403.52
7

Staurosporine, MedChemExpress

MedChemExpress Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 466.53
Color Light Yellow
Physical Form Powder
Chemical Name or Material Staurosporine
Grade Research
SMILES O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.0%
CAS 62996-74-1
Solubility Information DMSO : 62.5 mg/mL (133.97 mM; Need ultrasonic)
Synonym Antibiotic AM-2282 STS AM-2282
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H26N4O3
Formula Weight 466.53
8

VU0661013, MedChemExpress

MedChemExpress VU661013 is a potent and selective MCL-1 inhibitor.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 712.66
Color Light Yellow
Physical Form Solid
Chemical Name or Material VU0661013
Grade Research
SMILES ClC1=CC=C(C(CCCOC2=CC(C)=C(Cl)C(C)=C2)=C3N4[C@H](C)CN(C5=CN(C)C6=C5C=C(C(O)=O)C=C6)C3=O)C4=C1C7=C(C)N(C)N=C7C
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.52%
CAS 2131184-57-9
Solubility Information DMSO : ≥ 125 mg/mL (175.40 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C39H39Cl2N5O4
Formula Weight 712.66
9

JNJ-7777120, MedChemExpress

MedChemExpress JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 277.75
Color White
Physical Form Solid
Chemical Name or Material JNJ-7777120
Grade Research
SMILES O=C(C(N1)=CC2=C1C=CC(Cl)=C2)N3CCN(C)CC3
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.0%
CAS 459168-41-3
Solubility Information DMSO : ≥ 50 mg/mL (180.02 mM)
Health Hazard 1 H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C14H16ClN3O
Formula Weight 277.75
10

CAY10650, MedChemExpress

MedChemExpress CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 471.5
Color Off-White
Physical Form Solid
Chemical Name or Material CAY10650
Grade Research
SMILES O=C(CN1C(C=CC(C(O)=O)=C2)=C2C(C(C(C)C)=O)=C1)COC(C=C3)=CC=C3OC4=CC=CC=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 98.0%
CAS 1233706-88-1
Solubility Information DMSO : ≥ 43 mg/mL (91.20 mM)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H25NO6
Formula Weight 471.5
11

UNC2025, MedChemExpress

MedChemExpress UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 476.66
Color White
Physical Form Solid
Chemical Name or Material UNC2025
Grade Research
SMILES CN1CCN(CC2=CC=C(C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 96.86%
CAS 1429881-91-3
Solubility Information DMSO : 33.33 mg/mL (69.92 mM; Need ultrasonic and warming)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C28H40N6O
Formula Weight 476.66
12

GSK376501A, MedChemExpress

MedChemExpress GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

ENCOMPASS_PREFERRED
13

Entasobulin, MedChemExpress

MedChemExpress Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 439.89
Color Light Yellow
Physical Form Solid
Chemical Name or Material Entasobulin
Grade Research
SMILES O=C(C(NC1=CC(C=CC=N2)=C2C=C1)=O)C3=CN(C4=CC=CC=C43)CC5=CC=C(Cl)C=C5
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.04%
CAS 501921-61-5
Solubility Information DMSO : 155 mg/mL (352.36 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C26H18ClN3O2
Formula Weight 439.89
14

Amcasertib, MedChemExpress

MedChemExpress Amcasertib (BBI503) is an orally active and small-molecule multi-kinase inhibitor. Amcasertib exhibits inhibitory activity against the NANOG and CD133 expression and cell viability in PC-9/GR cells. As an orally available cancer cell stemness kinase inhibitor with potential antineoplastic activity, it is currently being studied in phase I clinical trials in a number of cancers.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 539.69
Color Yellow
Physical Form Solid
Chemical Name or Material Amcasertib
Grade Research
SMILES O=C(C1=C(C)NC(/C=C2C(NC3=C/2C=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=O)=C1C)NCCN(CC)CC
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.15%
CAS 1129403-56-0
Solubility Information DMSO : ≥ 30 mg/mL (55.59 mM)
Synonym BBI503
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C31H33N5O2S
Formula Weight 539.69
15

ML-098, MedChemExpress

MedChemExpress ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 309.36
Color White
Physical Form Solid
Chemical Name or Material ML-098
Grade Research
SMILES O=C(C1=CN(CCOC2=CC(C)=CC=C2C)C3=C1C=CC=C3)O
For Use With (Application) Cancer-Kinase/protease
Percent Purity 99.89%
CAS 878978-76-8
Solubility Information DMSO : ≥ 29 mg/mL (93.74 mM)
Synonym CID-7345532
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H19NO3
Formula Weight 309.36