A collection of genes utilized by the RNA interference (RNAi) pathway; the RNAi pathway is a biological process in which RNA molecules inhibit gene expression or translation by neutralizing targeted mRNA molecules. Ideal for genetic screening.
Silencer™ siRNA Libraries feature combinations of Silencer™ Pre-designed siRNAs, and when available, Silencer™ Validated siRNAs, in 96-well or 384-well plates.
These siRNA collections enable medium and high throughput analysis of phenotypes resulting from inhibition of large sets of targets from specific functional classes.
Ion channels are key components in a multitude of biological processes, including rapid changes in muscle cell contractions, epithelial transport of nutrients and ions, T cell activation and pancreatic beta-cell insulin release.
The Silencer™ Human Druggable Genome siRNA Library targets genes in the known druggable genome for performing RNAi functional screens for potential therapeutic targets.
Targets 904 genes with up to 4 gRNA per gene target for a total of 3,616 gRNAs. Libraries are delivered as 50μL of glycerol stock per gRNA and are also available as ready to use packaged lentivirus.
Targets 288 genes with up to 4 gRNA per gene target for a total of 1,152 gRNAs. Libraries are delivered as 50μL of glycerol stock per gRNA and are also available as ready to use packaged lentivirus
Targets 1,444 genes with up to 4 gRNA per gene target for a total of 5,776 gRNAs. Libraries are delivered as 50μL of glycerol stock per gRNA and are also available as ready to use packaged lentivirus.
DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.