CAS RN 1320288-17-2

IUPAC Name: N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine

Synonyms: N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-amine

Molecular Weight (g/mol): 621.92

Molecular Formula: C36H59N7O2

InChi Key: OUKWLRHRXOPODD-UHFFFAOYSA-N

SMILES: COC1=CC2=C(NC3CCN(CC3)C3CCCCC3)N=C(N=C2C=C1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C

Grade

Molecular Weight (g/mol)

Percent Purity

Physical Form

Quantity

MedChemExpress UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	621.9
Color	Off-White
Physical Form	Solid
Chemical Name or Material	UNC0646
Grade	Research
SMILES	COC1=CC2=C(NC3CCN(C4CCCCC4)CC3)N=C(N5CCN(C(C)C)CCC5)N=C2C=C1OCCCN6CCCCC6
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.13%
CAS	1320288-17-2
Solubility Information	DMSO : 50 mg/mL (80.40 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)
Health Hazard 1	H302
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₆H₅₉N₇O₂
Formula Weight	621.9

CAS RN 1320288-17-2

CAS RN 1320288-17-2

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