CAS RN 212844-54-7
CAS RN 212844-54-7
IUPAC Name:
2-chloro-4-({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(propan-2-yl)-9H-purin-6-yl}amino)benzoic acid
Synonyms:
purvalanol
Molecular Weight (g/mol):
432.91
Molecular Formula:
C20H25ClN6O3
InChi Key:
ZKDXRFMOHZVXSG-UHFFFAOYNA-N
SMILES:
CC(C)C(CO)NC1=NC(NC2=CC(Cl)=C(C=C2)C(O)=O)=C2N=CN(C(C)C)C2=N1
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Tocris Bioscience™ Purvalanol B
CAS: 212844-54-7 Molecular Formula: C20H25ClN6O3
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Purvalanol B, MedChemExpress
MedChemExpress Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum.
