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  5. Tocris Bioscience™ Purvalanol B

Tocris Bioscience™ Purvalanol B
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Product Code. 30001267
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30001267

Brand: Tocris Bioscience™ 1581/10

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This item is not returnable. View return policy

Description

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Purvalanol B is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 nM for cdk1 and cdk5, and 6 - 9 nM for cdk2, depending on binding partner). Purvalanol B is selective over a range of other protein kinases (IC50 >10,000 nM). Purvalanol B shows antiproliferative properties, mediated by ERK1 and ERK2. Purvalanol B induces autophagy in cellular models and induces apoptosis in cancer cells, the apoptotic effects can be increased by combining with Rapamycin (Cat. No. 1292).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 212844-54-7
Molecular Formula C20H25ClN6O3

Specifications

Quantity 10 mg
Formula Weight 432.91
Purity >99%
Molecular Weight (g/mol) 432.909
Chemical Name or Material Purvalanol B
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