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Thermo Scientific™ TheraPure™ 2'-Fluoro-Ac-C Phosphoramidite, 20-400 finish bottle

Product Code. 17944332 Shop All Thermo Scientific Products
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Product Code. 17944332 Supplier Thermo Scientific™ Supplier No. 27160409
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2'-Fluoro-Ac-C CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

2'-Fluoro-Ac-C CEP is a phosphoramidite containing 5' DMT and the nucleoside cytidine (C) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

TRUSTED_SUSTAINABILITY

Specifications

31P NMR Purity ≥98%
Format Amber bottle (20-400 finish neck style)
For Use With (Equipment) Expedite Synthesizers
Description Base: C
Base Protection: Ac
Molecular Weight (g/mol) 789.8 g/mol
Product Type 2in-Fluoro-Ac-C CEP
Content And Storage Store in freezer (at or below -20°C).
Nucleoside Type Cytidine (C)
Reagent Features 2in-Fluoro modified, Fast deprotection
Shipping Condition Room Temperature
Purity >98% (HPLC)
Quantity 0.25 g
Reagent Type Phosphoramidite
Grade TheraPure™
Nucleic Acid Type RNA
Product Line TheraPure
For Use With (Application) Oligonucleotide synthesis
Form Powder
Chemical Name or Material 5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-fluorocytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Molecular Formula C41H49N5FO8P
CAS 159414-99-0
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For Research Use Only. Not for use in diagnostic procedures.

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