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  6. Thermo Scientific Chemicals 5-Azacytidine, 99%

Thermo Scientific Chemicals 5-Azacytidine, 99%

Product Code. 10003160 Shop All Thermo Scientific Chemicals Products
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Quantity:
50 mg
1 g
Unit Size:
1g
50mg
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Product Code. 10003160

Brand: Thermo Scientific Chemicals 226620500

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Description

5-Azacytidine, CAS # 320-67-2, is an chemical analog of cytidine that acts as an inhibitor of DNA methyltransferase activity. | CAS: 320-67-2 | C8H12N4O5 | 244.21 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation
  • At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)

Applications

  • 5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells
  • It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation
  • 5-Azacytidine can globally change histone modification patterns
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 320-67-2
Molecular Formula C8H12N4O5
Molecular Weight (g/mol) 244.21
MDL Number MFCD00006539
InChI Key NMUSYJAQQFHJEW-KVTDHHQDSA-N
Synonym 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
PubChem CID 9444
ChEBI CHEBI:2038
IUPAC Name 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
SMILES NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

Specifications

CAS Min % 98.5
CAS Max % 100.0
Melting Point 228.0°C to 230.0°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass bottle
Quantity 50 mg
Merck Index 15, 884
Specific Rotation + 40.00
Solubility Information Solubility in water: .. Other solubilities: soluble in methanol
Formula Weight 244.21
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material 5-Azacytidine, 99%
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Safety and Handling

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Product Identifier
  • 5-Azacytidine
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • Germ cell mutagenicity Category 1B
 Hazard Statement
  • H340-May cause genetic defects.
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
SDS

RUO – Research Use Only

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