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  5. Tocris Bioscience™ ESI 1

Tocris Bioscience™ ESI 1

Product Code. 30485268
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30485268

Brand: Tocris Bioscience™ 8811/50

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This item is not returnable. View return policy

Description

Selective HDAC3 inhibitor; also myelination inducer

ESI 1 (epigenetic silencing inhibitor 1; also called PT3) is an HDAC3 inhibitor (IC50 = 250 nM). ESI 1 exhibits high selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8. Also, ESI 1 promotes remyelination in demyelinated animal models and enables de novo myelinogenesis on regenerated CNS axons. In vivo, ESI 1 enhances long-term memory in mouse model of novel object recognition. ESI 1 triggers nuclear condensate formation of lipid-metabolic regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. ESI 1 is orally bioavailable and blood-brain-barrier penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride
Quantity 50 mg
Target Class I Histone Deacetylases Inhibitors
Molecular Formula C18H17N5O.2HCl
Purity 98%
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