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Tocris Bioscience™ A 33
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Product Code. 18796036
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18796036

Brand: Tocris Bioscience™ 6313/10

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This item is not returnable. View return policy

Description

Potent and selective PDE4B inhibitor

A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
CAS 915082-52-9
Quantity 10 mg
Molecular Formula C19H18ClN3O2S
Formula Weight 387.88
Product Type Inhibitor
Purity 98%
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