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  5. Tocris Bioscience™ A 485

Tocris Bioscience™ A 485
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Product Code. p-7139256
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Product Code. Quantity unitSize
18733018 5 mg 5mg
18738649 25 mg 25mg
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Product Code. 18733018 Supplier Tocris Bioscience™ Supplier No. 6387/5

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291.60 EUR valid until 2026-03-31
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Description

Histone Acetyltransferase Inhibitors

A 485 is a potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively), which displays > 1000-fold selectivity over closely related HATs. A 485 suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro, and also inhibits tumor growth in a castration-resistant prostate cancer xenograft model. A 485 is orally bioavailable.

To request the negative control for A 485, please fill out the A 486 request form on the SGC website.

TRUSTED_SUSTAINABILITY

Specifications

CAS 1889279-16-6
Synonym (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2′,4′-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5′-oxazolidine]-3′-acetamide
Quantity 5 mg
Molecular Formula C25H24F4N4O5
Formula Weight 536.48
Purity 98%
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