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  5. STEMCELL Technologies A 83-01

STEMCELL Technologies A 83-01

Product Code. 17109971
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Product Code. Quantity unitSize
17109971 50 mg 50mg
17150012 5 mg 5mg
17160012 10 mg 10mg
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Product Code. 17109971

Brand: STEMCELL Technologies 1000245

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Description

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7

  • A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC50 = 12, 45, and 7.5 nM, respectively (Tojo et al.)
  • Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.)
  • In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.)
  • Inhibits mesoderm and endoderm specification (Zhang et al.)
  • Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.)

Specifications

CAS 909910-43-6
Quantity 50 mg
Molecular Formula C25H19N5S
Purity ≥95%
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