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Tocris Bioscience™ ABT 089 Dihydrochloride
High affinity and selective α4β2 nAChR partial agonist
Brand: Tocris Bioscience™ 5079/10
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Description
ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.Specifications
| ABT 089 dihydrochloride | |
| 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride | |
| Soluble to 100mM in water and to 20mM in DMSO | |
| Bioactive Small Molecule |
| 161416-61-1 | |
| 10 mg | |
| Solid |
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