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  5. Tocris Bioscience™ AMG 510

Tocris Bioscience™ AMG 510
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Product Code. 18769346
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18769346

Brand: Tocris Bioscience™ 7713/50

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This item is not returnable. View return policy

Description

Potent and selective KRASG12C inhibitor

AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
CAS 2252403-56-6
Quantity 50 mg
Target Ras GTPase Inhibitors
Molecular Formula C30H30F2N6O3
Purity 0.98
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