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Tocris Bioscience™ AT 1
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Product Code. 18738796
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5 mg
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Product Code. 18738796 Supplier Tocris Bioscience™ Supplier No. 6356/5

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Description

(+)-JQ1 based PROTAC with selectivity for BRD4

AT 1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC®) compound based on (+)-JQ1 (Cat.No. 4499) conjugated to a von Hippel-Lindau (VHL) ligand. Rationally designed based on a ternary complex crystal structure to improve selectivity for BRD4 degradation compared to MZ1 (Cat.No. 6154). Demonstrates profound and selective degradation of BRD4 in cells at 1-3 μM, with negligible loss of BRD2 and BRD3.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

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Specifications

Chemical Name or Material (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide
CAS 2098836-45-2
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C48H58ClN9O5S3
Formula Weight Observed MW: 972.68
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