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  5. Tocris Bioscience™ BAY 299

Tocris Bioscience™ BAY 299
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Product Code. 18704039
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5 mg
25 mg
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50mg
5mg
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18704039 25 mg 50mg
18726218 5 mg 5mg
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Product Code. 18704039 Supplier Tocris Bioscience™ Supplier No. 5970/25

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Description

Potent and selective BRD1 and TAF1 inhibitor

BAY 299 is a potent and selective BRD1 and TAF1 inhibitor (IC50 values are 6-67 and 8-13 nM, respectively). Displays selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). Displays BRD1 and TAF1 inhibition in a NanoBRET cell assay. Inhibits binding of BRD1 and TAF1 to histone H4 (IC50 values are 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 values are 825 nM and 1.4 μM, respectively).
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
CAS 2080306-23-4
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C25H23N3O4
Formula Weight Observed MW: 429.47
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