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  4. ACROBiosystems Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His, Avitag™ (SPR verified)

ACROBiosystems Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His, Avitag™ (SPR verified)

Product Code. p-7215552
Click to view available options
Quantity:
200 μg
25 μg
Unit Size:
200µg
25µg

Product Code. 16457519

Brand: ACROBiosystems FCMC82W3200ug

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Description

Biotinylated Protein

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag (SPR verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-

Specifications

Accession Number NP_001271480.1 (FCGRT) and N/A
Molecular Weight (g/mol) 34.1 kDa (FCGRT) and 11.6 kDa (B2M)
Quantity 200 μg
Source Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag (SPR verified), is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) and Q8SPW0-1 (B2M)). In the region Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M), the AA sequence of Cynomolgus and Rhesus macaque FcRn (FCGRT&B2M;) are homologus.
Immunogen Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M)
Storage Requirements -20°C
Gene Alias FcRn,FCGRT and B2M
Common Name FcRn (FCGRT and B2M)
Conjugate Precision Avi
Species Cynomolgus Monkey, Rhesus Macaque
Protein Tag His Tag and Avi Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype MABSol™ Biotin Labeled Proteins
Purity or Quality Grade >95% as determined by SDS-PAGE
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