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Tocris Bioscience™ BMS 536924
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Product Code. 30001638
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10 mg
Unit Size:
10mg
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Product Code. 30001638 Supplier Tocris Bioscience™ Supplier No. 4774/10

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Description

Dual IR/IGF1R inhibitor

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 468740-43-4
Molecular Formula C25H26ClN5O3

Specifications

Quantity 10 mg
Formula Weight 479.96
Purity >98%
Molecular Weight (g/mol) 479.965
Chemical Name or Material BMS 536924
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