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BB700 Mouse Anti-Human CD45RO, Clone UCHL1 (RUO)
Mouse monoclonal antibody that specifically binds to the 180 kDa isoform of CD45 (aka, the Leukocyte Common Antigen).
Brand: BD Biosciences 566521
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Description
- The UCHL1 monoclonal antibody specifically binds to the 180 kDa isoform of CD45 (aka, the Leukocyte Common Antigen).
- CD45RO is a type I transmembrane glycoprotein that has cytoplasmic protein tyrosine phosphatase activity and functions in signal transduction pathways.
- This CD45 isoform does not include amino acid sequences encoded by the variable CD45 exons A, B, or C.
- CD45RO is expressed on most thymocytes, activated T cells, memory T cells, granulocytes and monocytes, but only on a proportion of resting T cells.
- CD45RO and CD45RA antibodies seem to define complementary, predominantly non-overlapping, populations in resting peripheral T cells, demonstrating heterogeneity within the CD8 and CD4 subpopulations.
- CD45RO binds to CD22.
- The antibody was conjugated to BD Horizon BB700, which is part of the BD Horizon Brilliant™ Blue family of dyes.
- It is a polymer-based tandem dye developed exclusively by BD Biosciences.
- With an excitation max of 485 nm and an emission max of 693 nm, BD Horizon BB700 can be excited by the 488 nm laser and detected in a standard PerCP-Cy™5.5 set (eg., 695/40-nm filter).
- This dye provides a much brighter alternative to PerCP-Cy5.5 with less cross laser excitation off the 405 nm and 355 nm lasers.
Specifications
| CD45RO | |
| Monoclonal | |
| Brilliant Blue 700 (BB700) | |
| 100 Tests | |
| Secondary | |
| Human | |
| IgG2a κ |
| Flow Cytometry | |
| UCHL1 | |
| Mouse | |
| RUO | |
| CD45RO | |
| Refrigerate (2 to 8°C) |
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