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BB700 Mouse Anti-Human CD45RO, Clone UCHL1 (RUO)

Product Code. 15805129
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100 Tests
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Product Code. 15805129 Supplier BD Biosciences Supplier No. 566521

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Description

Mouse monoclonal antibody that specifically binds to the 180 kDa isoform of CD45 (aka, the Leukocyte Common Antigen).

  • The UCHL1 monoclonal antibody specifically binds to the 180 kDa isoform of CD45 (aka, the Leukocyte Common Antigen).
  • CD45RO is a type I transmembrane glycoprotein that has cytoplasmic protein tyrosine phosphatase activity and functions in signal transduction pathways.
  • This CD45 isoform does not include amino acid sequences encoded by the variable CD45 exons A, B, or C.
  • CD45RO is expressed on most thymocytes, activated T cells, memory T cells, granulocytes and monocytes, but only on a proportion of resting T cells.
  • CD45RO and CD45RA antibodies seem to define complementary, predominantly non-overlapping, populations in resting peripheral T cells, demonstrating heterogeneity within the CD8 and CD4 subpopulations.
  • CD45RO binds to CD22.
  • The antibody was conjugated to BD Horizon BB700, which is part of the BD Horizon Brilliant™ Blue family of dyes.
  • It is a polymer-based tandem dye developed exclusively by BD Biosciences.
  • With an excitation max of 485 nm and an emission max of 693 nm, BD Horizon BB700 can be excited by the 488 nm laser and detected in a standard PerCP-Cy™5.5 set (eg., 695/40-nm filter).
  • This dye provides a much brighter alternative to PerCP-Cy5.5 with less cross laser excitation off the 405 nm and 355 nm lasers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45RO
Applications Flow Cytometry
Classification Monoclonal
Clone UCHL1
Conjugate Brilliant Blue 700 (BB700)
Host Species Mouse
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Secondary
Test Specificity CD45RO
Target Species Human
Content And Storage Refrigerate (2 to 8°C)
Isotype IgG2a κ
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