missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD47 Monoclonal Antibody (B6H12), NovaFluor™ Red 725, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
191.00 € - 406.00 €
Specifications
| Antigen | CD47 |
|---|---|
| Clone | B6H12 |
| Concentration | 1 μg/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
Description
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes. CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.Specifications
| CD47 | |
| 1 μg/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide, pH 9.2 | |
| 9130415E20Rik, AA407862, AI848868, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, AW108519, B430305P08Rik, Cd47, CD47 antigen, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 antigen/integrin-associated protein, CD47 glycoprotein, CD47 molecule, CD47/IAP, IAP, integrin associated protein, integrin-associated protein, integrin-associated signal transducer, Itgp, Leukocyte surface antigen CD47, MER6, OA3, Protein MER6, Rh-related antigen, sCD47, soluble CD 47, soluble CD47 | |
| CD47 | |
| Primary | |
| 4°, C, store in dark, DO NOT FREEZE! |
| B6H12 | |
| Flow Cytometry | |
| NovaFluor Red 725 | |
| Mouse | |
| Human | |
| Q08722 | |
| 961 | |
| IgG1 κ | |
| Affinity chromatography | |
| CD47 |
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title