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BB700 Mouse Anti-Human CD56 Clone NCAM16.2 (NCAM16) (RUO)

Product Code. 15835159
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100 Tests
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Product Code. 15835159 Supplier BD Biosciences Supplier No. 566573

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Mouse monoclonal antibody that specifically binds to human CD56.

  • The NCAM16.2 monoclonal antibody specifically binds to human CD56.
  • It recognizes an extracellular immunoglobulin-like domain common to 120, 140, and 180 kDa forms of CD56, also known as the neural cell adhesion molecule (NCAM), NKH1 or MSK39.
  • The CD56 antigen is expressed on approximately 10% to 25% of peripheral blood lymphocytes.
  • It is present on essentially all resting and activated CD16+ natural killer (NK) lymphocytes and approximately 5% of CD3+ peripheral blood lymphocytes. CD3+ CD56+ T lymphocytes comprise a unique subset of cytotoxic T lymphocytes that mediates non-major histocompatibility complex (MHC)-restricted cytotoxicity.
  • CD56 antigen density on NK lymphocytes increases upon cellular activation.
  • The CD56 antigen is involved in neuronal homotypic cell adhesion and cell differentiation during embryogenesis.
  • CD16+ CD56+ NK cells demonstrate reciprocal transfer of an activation state with dendritic cells.
  • The antibody was conjugated to BD Horizon BB700, which is part of the BD Horizon Brilliant™ Blue family of dyes.
  • It is a polymer-based tandem dye developed exclusively by BD Biosciences.
  • With an excitation max of 485 nm and an emission max of 693 nm, BD Horizon BB700 can be excited by the 488 nm laser and detected in a standard PerCP-Cy™5.5 set (eg, 695/40-nm filter).
  • This dye provides a much brighter alternative to PerCP-Cy5.5 with less cross laser excitation off the 405 nm and 355 nm lasers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD56 (NCAM-1)
Applications Flow Cytometry
Classification Monoclonal
Clone NCAM16.2 (also known as NCAM 16)
Conjugate Brilliant Blue 700 (BB700)
Host Species Mouse
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Secondary
Test Specificity CD56 (NCAM-1)
Target Species Human
Content And Storage Refrigerate (2 to 8°C)
Isotype IgG2b κ
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