missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. Invitrogen™ Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein

Invitrogen™ Human CDK11/cyclin C, GST Tag, His Tag Recombinant Protein

Product Code. p-7180888
Click to view available options
Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
This item is not returnable. View return policy

Product Code. 15970413

Brand: Invitrogen™ A33511

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CDK11/cyclin C recombinant human protein (CDK11: 1-502, cyclin C: 1-283) was expressed in insect cells. CDK11/cyclin C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the LanthaScreen™ Eu Kinase Binding assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Recombinant, Active, Catalytic The gene accession number for CDK11 and cyclin C are NP_055891.1 and NP_005181.2.

Cyclin-dependent kinase 11 (CDK11, and also known as CDK19) and Cyclin C are key players in regulating transcription and cell cycle progression, particularly during apoptosis and cytokinesis. CDK11 exists in two major isoforms, CDK11p46 and CDK11p110, which are generated through alternative splicing and proteolytic processing. Cyclin C partners specifically with the CDK11p46 isoform, forming a complex that is involved in RNA splicing and mediating transcriptional responses necessary for cellular stress responses. CDK11's gene is located on human chromosome 1p36.3-p36.33 and its role in mediating cytokinesis involves phosphorylation of proteins that control the breakdown of the nuclear matrix and spindle formation. Cyclin C, when associated with CDK11, has been shown to have roles in the regulation of transcription factor activity, impacting the transcriptional program during cell cycle checkpoints. Aberrant expression and functioning of the CDK11/Cyclin C complex have been implicated in tumorigenesis, highlighting its importance in cancer biology. Furthermore, CDK11 is essential for maintaining mitochondrial integrity and function, thus further broadening its influence on cellular health beyond mere transcriptional control.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P24863, Q9BWU1
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM HEPES with 100mM NaCl, 20% glycerol, 5mM DTT and no preservative; pH 7.5
Gene ID (Entrez) 23097, 892
Molecular Weight (g/mol) 84.9-38.0 kDa
Name Human CDK11/cyclin C, GST Tag, His Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias 2700084L06Rik; AI845279; AW228747; bA346C16.3; Cdc2l6; CDC2-related protein kinase 6; Cdk11; Cdk19; CDK8-like cyclin-dependent kinase; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; cyclin dependent kinase 19; cyclin dependent kinase 19 variant 2; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; Cyclin-dependent kinase 19; death-preventing kinase; KIAA1028; mKIAA1028
Common Name CDK11/cyclin C
Gene Symbol CCNC, CDK19
KinaseFamily CDKs and CHKs
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag, His-tag
Sequence CDK11: 1-502, Cyclin C: 1-283
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Shipping Condition Dry Ice
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Recombinant, Active, Catalytic
Form Liquid
Show More Show Less
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.