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Thermo Scientific™ CellSensor™ ISRE-bla RA-1 Cell Line

Product Code. 10497883
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Product Code. 10497883 Supplier Thermo Scientific™ Supplier No. K1674

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Description

The CellSensor™ ISRE-bla RA-1 Cell Line contains the beta-lactamase (bla) gene under the control of the interferon-stimulated response element (ISRE).

The CellSensor™ ISRE-bla RA-1 Cell Line contains the beta-lactamase (bla) gene under the control of the interferon-stimulated response element (ISRE). This cell line was engineered by lentiviral transduction of an ISRE-bla construct into RA-1 cells. Flow cytometry was then used to isolate a pool of cells responsive to polyinosinic-polycytidylic acid (poly I:C) stimulation. ISRE-bla RA-1 cells have been tested for assay performance using variable assay conditions, including DMSO concentration, cell number, stimulation time, substrate loading time, as well as validated for Z'-factor and EC50 concentrations of poly I:C. Additional testing data using alternate stimuli are also available. Academic and non-profit customers, please inquire for special pricing.

TRUSTED_SUSTAINABILITY

Specifications

Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Description CellSensor™ ISRE-bla RA-1 Cell Line, 1Vial, ∽ 5,000,000 cells/vial at 5,000,000 cells/mL Quantity of Cells, ISRE-bla RA-1 Cell Line, Fluorescent Detection Method, CellSensor™ Druggable Target, Suspension Growth Properties, Liquid Nitrogen Storage
Detection Method Fluorescent
For Use With (Application) Pharma and biopharma, drug discovery and development, target and lead identification and validation, pathway biology, cellular pathway analysis assays, cellsensor™ cellular pathway assays
Includes beta-lactamase gene under the control of the interferon stimulated response element (ISRE)
Product Line CellSensor
Quantity 1 Vial
Sample Type ISRE-bla RA-1
Target Entry TLR3/TBK1/IRF3 pathway, TBK1, IRF3, TLR3
Type Cell Line
System Type CellSensor™
Druggable Target Signaling Pathway
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For Research Use Only. Not for use in diagnostic procedures.

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