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Tocris Bioscience™ Centrinone
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Product Code. 18758578
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18758578

Brand: Tocris Bioscience™ 5687/10

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This item is not returnable. View return policy

Description

High affinity and selective PLK4 inhibitor

High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.

Centrinone is a high affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine
CAS 1798871-30-3
Quantity 10 mg
Target Polo-like Kinase Inhibitors
Molecular Formula C26H25F2N7O6S2
Formula Weight 633.65
Purity >98%
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