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  6. Thermo Scientific™ CHAPSO (3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate)

Thermo Scientific™ CHAPSO (3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate)

Product Code. 30245085 Shop All Thermo Scientific Products
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Product Code. 30245085 Supplier Thermo Scientific™ Supplier No. A65501
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Description

CHAPSO, or 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate, is a zwitterionic detergent commonly used in biochemical and biophysical research.

CHAPSO, or 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate, is a zwitterionic detergent commonly used in biochemical and biophysical research. It is widely employed for membrane protein solubilization, stabilization, and purification. CHAPSO is known for its mildness and ability to preserve the structural integrity and functionality of membrane proteins during extraction. Its unique properties make it suitable for a variety of applications, including protein crystallization, spectroscopy, and structural biology studies. With its versatile and effective solubilization capabilities, CHAPSO is a valuable tool for researchers working with membrane proteins.

Features of CHAPSO include:

  • Zwitterionic detergent
  • Gentle—enabling preservation of native conformation and activity
  • Effectively disrupts lipid-protein interactions
  • Exhibits low critical micelle concentration (CMC)
  • High-purity compound with low UV absorptivity

Properties

  • CMC: (H2O) ∼8 mM (0.50%)
  • Aggregation number: (H2O) ∼11
  • Purity: ≥99% (by HPLC analysis)
  • pH: 5–8 (1% solution in water)
  • Solubility: ≥0.5 M (in water at 20 °C)
  • Fluorescence: <10% (0.1% solution in water at 345 nm)
  • Absorbance of a 1% solution in water: 260 nm: <0.06, 280 nm: <0.04, 340 nm: <0.02
TRUSTED_SUSTAINABILITY

Specifications

Color White
Product Type Detergent
CAS 82473-24-3
Molecular Formula C32H58N2O8S
Solubility ≥0.5 M (in water at 20°C)
Content And Storage Store below -20°C.
Form Lyophilized
Reagent Type Detergent
Purification Target Proteins
Quantity 1 g
Molecular Weight (g/mol) 630.9
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For Research Use Only.

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