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CM 11, Tocris Bioscience™
Homo-PROTAC™ for self-degradation of pVHL30
Brand: Tocris Bioscience 6416/5
This item is not returnable.
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Description
CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifications
| 2244684-49-7 | |
| N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide | |
| 5 mg |
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