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  7. CX-5461 dihydrochloride, MedChemExpress

CX-5461 dihydrochloride, MedChemExpress

Product Code. 16435648
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Product Code. 16435648

Brand: Medchem Express HY13323A

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Description

MedChemExpress CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).

CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).

Specifications

Chemical Name or Material CX-5461 dihydrochloride
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C27H29Cl2N7O2S
Quantity 10 mg
Solubility Information H2O : ≥ 25 mg/mL (42.62 mM)
SMILES CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1.[2 HCl]
Molecular Weight (g/mol) 586.54
Formula Weight 586.54
Percent Purity 98.07%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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