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Tocris Bioscience™ Dacomitinib
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Product Code. 18735966
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18735966 50 mg 50mg
18719776 10 mg 10mg
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Product Code. 18735966 Supplier Tocris Bioscience™ Supplier No. 6231/50

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Description

Potent irreversible pan ErbB inhibitor

Dacomitinib is a potent irreversible pan ErbB inhibitor (IC50 values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively). Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant to Iressa (Cat. No. 3000). Inhibits tumor growth. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
CAS 1110813-31-4
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C24H25ClFN5O2
Formula Weight Observed MW: 469.94
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