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Thermo Fisher Scientific DDM/CHS Solution (10:1)
A ready-to-use solution for solubilization of membrane proteins while maintaining structural integrity and activity.
Brand: Thermo Fisher Scientific A50942
Additional Details : Weight : 0.00200kg
Description
- A ready-to-use solution for solubilization of membrane proteins while maintaining structural integrity and activity
- The stable pre-formulated solution contains a mixture of dodecyl-β-D-maltoside (DDM) (100 mg/mL) and cholesteryl hemisuccinate (CHS) (10 mg/mL) in deionized water with final concentrations of 10% and 1%, respectively
- Typical working concentrations are 1% DDM/0.1% CHS for protein extraction and 0.1% DDM/0.01% CHS for protein purification
Features of DDM/CHS Solution include:
- Ready-to-use liquid formulation
- Mixture of nonionic detergent, DDM, with dual hydrophobic/hydrophilic properties and anionic detergent, CHS, that aids in the stabilization of large unilamellar vesicles
- DDM/CHS micelles aid in solubilization of membrane proteins while preserving structure and function
- Suitable for protein solubilization and stabilization for single particle cryo-EM analysis
Properties of DDM:
- Molecular formula: C24H46O11
- Molecular weight: 510.6 g/mol
- Detergent class: Non-ionic
- Micelle molecular weight: 50,000 g
- Critical micelle concentration (CMC): 0.17 mM (0.009% w/v) in water; 0.12 mM (0.006% w/v) in 0.2 M NaCl
Properties of CHS:
- Molecular formula: C31H50O4 · C4H11NO3
- Molecular weight: 607.9 g/mol
- Detergent: Ionizable anionic
- Function: Stabilizes large unilamellar vesicles
Specifications
| Liquid | |
| 10 x 1 mL |