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R&D Systems™ DMH-1

Product Code. 18005362
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Product Code. 18005362 Supplier R&D Systems™ Supplier No. 4126/10
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Description

A Tocris product, part of R&D Systems. Selective ALK2 inhibitor

DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs).
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1206711-16-1
Molecular Formula C24H20N4O

Specifications

Quantity 10 mg
Product Line Tocris
Formula Weight 380.44
Purity >98%
Molecular Weight (g/mol) 380.45
Chemical Name or Material DMH-1
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