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EED226, MedChemExpress

Product Code. 16469816
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Product Code. 16469816 Supplier Medchem Express Supplier No. HY101117

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Description

MedChemExpress EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model. EED226 is a potent, selective, and orally bioavailable EED inhibitor. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays.

Specifications

Chemical Name or Material EED226
CAS 2083627-02-3
Color Off-White
Purity Grade Notes Research
Molecular Formula C17H15N5O3S
Quantity 50 mg
Solubility Information DMSO : ≥ 29 mg/mL (78.51 mM)
SMILES O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Molecular Weight (g/mol) 369.4
Formula Weight 369.4
Percent Purity 98.61%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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