Thermo Scientific™ Endonuclease V, T.maritima (5 U/μL)

Degrade DNA with Endonuclease V, T. maritima (Endo V), a 3'-endonuclease involved in DNA repair that initiates removal of deaminated bases from damaged DNA.

Endonuclease V, T. maritima (Endo V) is a 3'-endonuclease involved in DNA repair, which initiates removal of deaminated bases from damaged DNA, including uracil, hypoxanthine, and xanthine (see Figure 1).

Endonuclease V is also active toward abasic sites and urea sites, base pair mismatches, flap and pseudo Y structures, and small insertions/deletions in DNA molecules. The cleavage site generated by Endonuclease V is at the second phosphodiester bond 3' to a lesion.