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STEMCELL Technologies EX527

Product Code. 17180252
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 17180252

Brand: STEMCELL Technologies 73654

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This item is not returnable. View return policy

Description

Epigenetic modifier; Inhibits SIRT1 histone deacetylase

  • EX527 is a cell-permeable, selective inhibitor of mammalian sirtuin 1 (SIRT1; IC50 = 98 nM) over SIRT2 and SIRT3 and has no effect on other histone deacetylases (HDACs; Nayagam et al.) SIRT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase with roles in energy metabolism and inflammation
  • Studies have shown that EX527 inhibits sirtuins by forming a trimeric sirtuin complex with an NAD+-derived coproduct (Gertz M et al.)
  • Increases the production of oligodendrocytes from differentiating neural stem cells and neural progenitor cells in vitro (Rafalski et al.)
  • Restores the microvascular response during the hypoinflammatory phase in a mouse model of sepsis, and enhances the systemic innate immune response (Vachharajani et al.)
  • Delays cyst growth in kidneys of PKD1 knockout mouse models (Zhou et al.)

Specifications

CAS 49843-98-3
Synonym Selisistat
Quantity 10 mg
Molecular Formula C13H13ClN2O
Purity ≥98%
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