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Thermo Scientific™ EZ-Link™ Alkoxyamine-PEG4-Biotin

Product Code. 11388251 Shop All Thermo Scientific Products
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Quantity:
50 mg
Unit Size:
50mg
Product Code. Quantity unitSize
11388251 50 mg 50mg
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Product Code. 11388251

Brand: Thermo Scientific™ 26137

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Description

Biotinylate glycoproteins (aldehydes of oxidized sugars) with a mid-length (27.0A), pegylated biotinylation reagent containing a 4-unit PEG spacer for length and solubility.

Thermo Scientific™ EZ-Link Alkoxyamine-PEG4-Biotin is a biotinylation reagent containing a four-unit polyethylene glycol (PEG) spacer for biotinylating macromolecules at carbohydrate groups that have been oxidized to form aldehydes.

Alkoxyamine-activated biotinylation reagents such as this one are useful for biotin-labeling glycoproteins and other molecules that have oxidizable polysaccharides groups. EZ-Link Alkoxyamine-PEG-Biotin reagents contain a multi-functional extended spacer arm that is a flexible, non-immunogenic hydrophilic polyethylene glycol (PEG), which imparts water solubility to labeled molecules. Consequently, antibodies labeled with biotin alkoxyamine reagents exhibit less aggregation when stored in solution compared to antibodies labeled with reagents having only hydrocarbon spacers.

Highlights:

  • Biotin – label macromolecules for detection or affinity purification with avidin and streptavidin

  • Alkoxyamine-activated – reacts with aldehyde groups (e.g., oxidized sugars in glycoproteins) to attach biotin by stable oxime bonds

  • Polyethylene glycol – PEG groups are flexible, non-immunogenic, hydrophilic, and improve the solubility of labeled antibodies

  • Spacer arm – the reach between the point of attachment and the biotin affinity tag is nearly 27 angstroms, sufficient to minimizing steric hindrance for binding

Specifications:

  • Chemical formula: C18H34N4O6S
  • Molecular weight: 434.55
  • Spacer arm: 27.0 angstroms
  • Net mass added to target: 416.53
  • Form: white solid
  • Solubility: dissolve in DMSO to make 250mM stock
TRUSTED_SUSTAINABILITY

Specifications

Product Type Alkoxyamine-PEG4-Biotin
Quantity 50 mg
Content And Storage Store at -20°C. Shipped at ambient temperature.
Product Line EZ-Link
Cell Permeability Cell-Impermeant
Chemical Reactivity Ketone, Aldehyde
Reactive Moiety Alkoxyamine
Solubility DMF (Dimethylformamide), DMSO (Dimethylsulfoxide), Water
Label or Dye Biotin
Spacer Long, Pegylated
Label Type Biotin & Analogs
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For Research Use Only. Not for use in diagnostic procedures.

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