missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18798546

Tocris Bioscience™ Gefitinib-based PROTAC™ 3
GREENER_CHOICE

Product Code. 18798546
Click to view available options
Quantity:
5 mg
Unit Size:
5mg
This item is not returnable. View return policy

Product Code. 18798546

Brand: Tocris Bioscience™ 7258/5

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent EGFR PROTAC™

Gefitinib-based PROTAC® 3 is a potent EGFR PROTAC™ Degrader. Comprises an EGFR inhibitor gefitinib (Iressa Cat.No. 3000) conjugated to a VHL ligand via a linker. Induces EGFR degradation (DC50 values are 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively). Exhibits no degradation of wild-type EGFR at concentrations up to 10 μM.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS 2230821-27-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C47H57ClFN7O8S
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.