missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. 10491795

Gibco™ Human TGF-beta 3 Recombinant Protein

Product Code. 10491795
Change view
Click to view available options
Quantity:
5 μg
Unit Size:
Each
Product Code. Quantity unitSize
10491795 5 μg Each
1 options
This item is not returnable. View return policy

Product Code. 10491795

Brand: Gibco™ PHG9305

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

Purity: >98% by SDS-PAGE and HPLC, Endotoxin Concentration: <0.1 ng/μg, Protein Length: 112 aa (2 identical subunits), Biological Activity: ED50 ≤0.05 ng/mL, Molecular Weight: 17.5 kDa

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P10600
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation 0.12% acetic acid with 20% ethanol and no preservative
Gene ID (Entrez) 7043
Molecular Weight (g/mol) 25.4 kDa
Name Human TGF-beta 3
Purification Method Sequential Chromatography
Quantity 5 μg
Source Human
Endotoxin Concentration <0.1 ng/ μg
Gene Alias ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
Common Name TGF beta-3
Biological Activity ED50 ≤ 0.05 ng/mL (≥ 12.5 x 10e6 IU/mg); determined by a toxicity assay using the WHO Standard 98/608 for direct comparison.
Conjugate Unconjugated
Recombinant Recombinant
Sequence Human TGF-beta 3 recombinant protein is a homodimer containing two 112 amino acid subunits
Content And Storage 4°C
Expression System E. coli
Protein Family Growth Factors & Receptors
Form Liquid
Protein Subtype TGFs (Transforming Growth Factors)
Purity or Quality Grade >98% by SDS-PAGE and HPLC
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.