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  5. Tocris Bioscience™ GSK 2193874

Tocris Bioscience™ GSK 2193874
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Product Code. 18750809
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18750809 5 mg 5mg
18757646 25 mg 25mg
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Product Code. 18750809 Supplier Tocris Bioscience™ Supplier No. 5106/5

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Description

Potent and selective TRPV4 antagonist; orally active

GSK 2193874 is a potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ∽200 human receptors, channels and enzymes. Orally active.
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Specifications

Chemical Name or Material 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS 1336960-13-4
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C37H38BrF3N4O
Formula Weight Observed MW: 691.62
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