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Tocris Bioscience™ GW 4869
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Product Code. 18796266
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18796266

Brand: Tocris Bioscience™ 6741/10

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This item is not returnable. View return policy

Description

Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor

GW 4869 is a selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3,3 '-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1 H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate
Quantity 10 mg
Target Hydrolase Inhibitors
Molecular Formula C30H28N6O20.2 CF3COOH
Purity 0.9
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