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Gibco™ Human Apo-SAA Recombinant Protein, PeproTech®

Product Code. 17840243
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Product Code. Quantity unitSize
17840243 250 μg 250µg
17861883 100 μg 100µg
17860163 10 μg 10µg
17831213 1 mg 1mg
17830623 500 μg 500µg
17871813 50 μg 50µg
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Product Code. 17840243 Supplier Gibco™ Supplier No. 30013250UG

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Recombinant Protein

Recombinant Apo-SAA is a consensus SAA molecule corresponding to human Apo-SAA1alpha, except for the presence of an N-terminal methionine, the substitution of asparagine for aspartic acid at position 60, and arginine for histidine at position 71 (the latter two substituted residues are present in Apo-SAA2beta). The calculated molecular weight of Recombinant Human Apo-SAA is 11.7 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The serum amyloid A family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P0DJI8
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 6288
Molecular Weight (g/mol) 11.7 kDa
Name Human Apo-SAA
Purification Method Purified
Quantity 250 μg
Source E. coli
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias amyloid a; Amyloid fibril protein AA; Amyloid protein A; MGC111216; PIG4; SAA; SAA1; Saa-1; Saa2; serum amyloid A; serum amyloid A 1; serum amyloid A 2; serum amyloid A protein; serum amyloid A1; Serum amyloid A1 protein; Serum amyloid A-1 protein; serum amyloid A-like protein; Serum amyloid protein A(2-102); Serum amyloid protein A(2-103); Serum amyloid protein A(2-104); Serum amyloid protein A(3-104); Serum amyloid protein A(4-101); Serum Amyloid-A; TP53I4; tumor protein p53 inducible protein 4
Common Name SAA
Gene Symbol SAA1
Biological Activity Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 uM. * Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS NARENIQRFF GRGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY
Content And Storage -20°C
Activity Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 uM. * Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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