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Gibco™ Human BMP-4, Animal-Free Recombinant Protein, PeproTech®

Product Code. 17886548
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17886548 50 μg 50µg
17866548 250 μg 250µg
17886468 2 μg 2µg
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Product Code. 17886548 Supplier Gibco™ Supplier No. AF12005ET50UG

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456.00 EUR valid until 2026-06-30
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Description

Recombinant Protein

AF-120-05ET-1MG will be provided as 2 x 500 μg (AF-120-05ET-500UG). PeproTech's E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, and includes a N-terminal Met residue. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P12644
For Use With (Application) Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 652
Molecular Weight (g/mol) 24.2 kDa
Name Human BMP-4, Animal-Free
Purification Method Purified
Quantity 50 μg
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/μg
Gene Alias BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Common Name BMP4
Gene Symbol BMP4
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR
Content And Storage -20°C
Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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