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Gibco™ Human BMP-4 Recombinant Protein, PeproTech®

Product Code. 17811153
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Product Code. Quantity unitSize
17811153 5 μg 5µg
17800943 100 μg 100µg
17821043 1 μg 1µg
17810473 50 μg 50µg
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Codice prodotto. 17811153 missing translation for 'mfr' Gibco™ missing translation for 'supplierNo' 120055UG
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Descrizione

Recombinant Protein

120-05-1MG will be provided as 10 x 100 μg (120-05-100UG). 120-05-500UG will be provided as 5 x 100 μg (120-05-100UG). Recombinant Human BMP-4, expressed in HeLa cells, is a 25.6 kDa homodimeric glycoprotein. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
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Specifica

Accession Number P12644
For Use With (Application) Control, Western Blot Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 652
Molecular Weight (g/mol) 25.6 kDa
Name Human BMP-4
Purification Method Purified
Quantity 5 μg
Source HeLa cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias BMP; BMP2B; BMP-2B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Common Name BMP4
Gene Symbol BMP4
Biological Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR
Content And Storage -20°C
Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2-8 ng/ml.
Expression System HeLa cells
Form Lyophilized
Purity or Quality Grade ≥ 97% by SDS-PAGE gel and HPLC analyses.
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