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Invitrogen™ Human CDK4 Recombinant Protein
Description
This product contains purified recombinant human CDK4 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Specifications
Specifications
| Accession Number | P11802 |
| Concentration | 0.081 mg/mL |
| For Use With (Application) | Control, Western Blot |
| Formulation | 0.01 M Bis-tris propane with 0.1 M NaCl, 50% glycerol and no preservative; pH 9.0 |
| Gene ID (Entrez) | 1019 |
| Molecular Weight (g/mol) | 38 kDa |
| Name | Human CDK4 |
| pH Range | 9.0 |
| Quantity | 1 mg |
| Source | E. coli |
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