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ACROBiosystems Human DPPIV / CD26 Protein, His Tag (Active dimer) (active enzyme)

Product Code. 15886587
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Product Code. 15886587 Supplier ACROBiosystems Supplier No. DP4H522150UG

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Description

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 85.7 kDa. The protein migrates as 95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

Accession Number NP_001926.2
Molecular Weight (g/mol) 85.7 kDa
Quantity 50 μg
Source Human DPPIV, His Tag (DP4-H5221) is expressed from human 293 cells (HEK293). It contains AA Asp 34 - Pro 766 (Accession # NP_001926.2).
Immunogen Asp 34 - Pro 766
Storage Requirements -20°C
Gene Alias DPP4,ADABP,ADCP2,CD26,DPPIV,TP103
Common Name DPPIV
Conjugate Unconjugated
Species Human
Protein Tag His Tag
Buffer PBS, pH7.4
Endotoxin Level Less than 1.0 EU / μg by the LAL method.
Expression System HEK293
Form Powder
Protein Subtype Enzymes
Purity or Quality Grade >95% as determined by SDS-PAGE
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